Tenofovir-induced nephrotoxicity refers to kidney damage caused by the antiviral medication tenofovir. There are several synonyms for this condition, including tenofovir nephropathy, tenofovir-associated renal dysfunction, and tenofovir-induced kidney injury. A common manifestation of this condition is proximal tubular damage leading to impaired reabsorption of important nutrients and electrolytes. Patients may experience symptoms such as decreased urine output, fatigue, and bone pain. If left untreated, tenofovir-induced nephrotoxicity can progress to renal failure. Patients receiving tenofovir therapy should be monitored regularly for any signs of kidney dysfunction. Early detection and management are crucial to prevent irreversible kidney damage.