The term "the great unknowns" is often used to refer to things that are unfamiliar or uncertain. Some synonyms for this phrase include "the unexplored territory," "the mystery," "the enigma," and "the uncharted waters." Other phrases that could be used to describe this concept include "the uncharted territory," "the undiscovered country," and "the untested waters." Whatever phrase is used, it conveys the idea that there is much that humans do not yet know, and that there are plenty of mysteries left to be explored and understood. These synonyms are particularly apt for describing topics related to science, exploration, and adventure.