The thiol-yne reaction is a chemical process that involves the reaction of thiol and alkyne functional groups. This reaction is also referred to as the thiol-alkyne reaction or the thiol-ene reaction. Other synonyms for this process include the click reaction, the radical-mediated coupling reaction, and the Huisgen-Meldal-Sharpless reaction. The thiol-yne reaction has a wide range of applications in materials science, organic synthesis, and bioconjugation. Its ability to create complex molecules with high precision and efficiency makes it an essential tool for the development of new pharmaceuticals and materials. As such, the thiol-yne reaction is a critical reaction in the realm of chemical research and development.