Transneuronal retrograde degenerations refer to the phenomenon in which neurons connected to one another in a neural circuit tend to degenerate when the target neuron in the circuit is damaged or lost. This intricate process occurs as a result of disruptions in neuronal signaling and connectivity. Synonyms for transneuronal retrograde degenerations include retrograde neuronal degeneration or transneuronal retrograde atrophy. These terms are often used interchangeably to describe the retrogressive breakdown of neural connections. Understanding these synonyms is crucial in the field of neuroscience as they shed light on the mechanisms underlying neurodegenerative diseases and injuries, aiding in the development of potential treatments and interventions.