A synonym for the term "true chancre" is "primary syphilitic lesion". A true chancre is a distinct, painless ulcer that appears at the site of initial infection with the sexually transmitted infection, syphilis. It typically occurs within 3 weeks to 3 months after exposure to the bacteria. This lesion is highly contagious and commonly found on the genitals, anus, or mouth. It is characterized by a firm, raised edge and a clean base. The term "primary syphilitic lesion" is often used interchangeably with true chancre to describe this specific hallmark of syphilis infection. Early detection and treatment of true chancres are crucial to prevent further progression of the disease.