Tumefacient is a rather obscure word that is not frequently used in everyday conversation. However, if you're familiar with the word, you may be interested to learn about some of its synonyms. Some possible words that could be used in place of tumefacient include swelling, inflaming, engorging, puffing, enlarging, distending, and ballooning. Each of these words describes something that is becoming larger, whether due to inflammation, fluid accumulation, or some other cause. Some of these words are more commonly used than others, so it's important to choose the synonym that best suits the context and audience you're writing for.