The term "un-instructed" refers to someone or something that lacks knowledge or has not been taught. Therefore, its antonyms are words that describe the opposite, indicating a degree of knowledge or learning. Some possible alternatives to "un-instructed" include educated, trained, skilled, experienced, knowledgeable, informed, cultivated, refined, sophisticated, and worldly. These terms imply a level of proficiency, awareness, or expertise in a particular area or field. They suggest that the person or thing described has acquired insight, comprehension, or mastery through study, practice, or exposure. Thus, the antonyms of "un-instructed" represent a range of positive attributes and capabilities that contribute to personal growth and success in various domains of life.