"Up and do" is a commonly used phrase that urges someone to take action or start doing something. There are many synonyms for this phrase which can be used in different contexts, depending on the situation. Some possible alternatives to "up and do" include "get to work," "take action," "start now," "make a move," "begin immediately," "get started," "take the plunge," and "get cracking." These synonyms all convey a sense of urgency and encourage individuals to take action instead of procrastinating or delaying important tasks. Choosing the right synonym depends on the context and the tone of the message being conveyed.