Up the spout is an idiomatic phrase that refers to something that is ruined, lost, or wasted. If you're looking for synonyms that convey the same meaning, you might consider phrases like "kaput," "shot," "lost cause," or "down the drain." Other options include "ruined," "failed," "busted," "spoiled," "irreparable," and "irrecoverable." Each of these expressions conveys a sense of finality or hopelessness, suggesting that whatever has gone up the spout cannot be retrieved or repaired. Ultimately, the choice of synonym will likely depend on the context in which you're using the phrase and the tone or mood you're trying to convey.