The phrase "while subject" is often used to describe a main topic or theme that is being discussed. There are a variety of synonyms that can be used in place of this phrase, each with its own unique connotation. For example, the term "central theme" can be used to describe the main idea or focus of a piece of writing or conversation. Additionally, the term "key subject" implies that the topic being discussed is of utmost importance or relevance. Other synonyms include "primary topic", "main point", and "core theme". Ultimately, the choice of synonym will depend on the context and tone of the conversation or written work.