Whistle stops, often referred to as small towns or villages, can have a variety of antonyms depending on context. In the sense of being remote or isolated, antonyms could include bustling cities, urban centers, or metropolitan areas. If referring to a place with few amenities, antonyms might include places with infrastructure like shopping centers, schools, or hospitals. Another antonym might be a destination, as opposed to a passing-through point. It is worth noting that the term "whistle stop" often has a positive connotation of quaintness, charm, and simplicity, so some potential antonyms may not necessarily be fitting substitutes.