When it comes to expressing the need to handle something delicately or attentively, there are plenty of synonyms for the phrase "with care." Some interchangeable phrases include "with caution," "with prudence," "with diligence," and "with attention to detail." Other options could be "with sensitivity," "with precision," "with thoughtfulness," or "with mindfulness." Each of these convey the importance of taking extra care in the handling of a matter, whether it be physical or emotional. Ultimately, the use of any synonym for "with care" serves to emphasize a sense of responsibility and attentiveness towards the task at hand.