There are a variety of synonyms for the phrase "witty comment," each with their own connotations and shades of meaning. Some possibilities include humorous quip, clever remark, funny retort, amusing comeback, sardonic observation, dry wit, droll statement, tongue-in-cheek response, wry joke, and playful barb. These phrases all suggest a certain level of intelligence, humor, and wordplay, and could be used in a wide range of contexts, from casual conversations to formal settings such as speeches or presentations. Depending on the specific context and intended tone, each of these phrases could be an effective tool for injecting humor and wit into a conversation or interaction.