When one works tirelessly day in and day out, it can be described in various ways. A common synonym for "working day and night" is "working round the clock". It suggests that the person is working tirelessly without a break. Another common expression is "burning the midnight oil". This phrase has been in use since the 17th century and is often used to describe a person who is working late into the night. One can also use the phrase "working non-stop", which suggests that the person is continuously working without any breaks. Similarly, "working tirelessly" implies that the person is putting in a lot of effort and dedication into their work without taking breaks. Overall, there are various synonyms to describe working day and night that convey the same message of dedication and hard work.