"You lose" is a phrase commonly used to indicate defeat or failure. However, there are many synonyms that can be used to convey this same message. Some possible alternatives include "you fail," "you're beaten," "you're defeated," "you're out," "you're vanquished," and "you're bested." These words all carry a similar sense of defeat, but may be more or less appropriate depending on the context in which they are used. Ultimately, the choice of synonym will depend on the specific situation, as well as the speaker or writer's tone and intended audience.