Zellweger Disease is a rare genetic disorder that affects the functioning of various organs, primarily the brain, liver, and kidneys. Also known as Zellweger Syndrome or cerebrohepatorenal syndrome, it is an inherited condition that hampers the ability to break down very long-chain fatty acids. This leads to an accumulation of these fatty acids in the body's cells, causing severe damage to organs. The disease is characterized by developmental delays, poor muscle tone, hearing and vision loss, and liver dysfunction. Although there are no known synonyms for Zellweger Disease, it is crucial to raise awareness about this condition to aid in early diagnosis and management.