Zoloft is the brand name for sertraline, which is an antidepressant medication. There are several synonyms for Zoloft, including sertraline hydrochloride, sertraline HCL, and Lustral. These names refer to the same medication, which is commonly used to treat depression, anxiety, and obsessive-compulsive disorder (OCD). Some other medications that are similar to Zoloft include Prozac, Paxil, and Lexapro. These medications also belong to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is important to talk to a doctor before starting any medication and to follow their instructions carefully to ensure safe and effective treatment.