The phrase "and how" is often used to add emphasis to a statement or question. However, there are various synonyms that can be used to convey a similar meaning. "Indeed" is a classic alternative that can be used to express agreement and emphasis. "Absolutely" and "certainly" also work well in this context. For a more casual tone, "you bet" and "you know it" can express agreement and enthusiasm. Other options include "no doubt," "definitely," and "without a doubt." Ultimately, the choice of synonym will depend on the tone and context of the statement.