The phrase "are up and about" implies that someone is awake, active, and moving around. Some antonyms for this phrase could include "asleep and still," "sedentary and stagnant," or "lying down and resting." These are all terms that describe a state of inactivity or repose, rather than the energy and motion suggested by "up and about." Other opposite words might include "unconscious and immobile," "prostrate and lethargic," or "inert and stationary." Depending on the context or the reason someone might not be "up and about," there could be numerous antonyms that capture the opposite state or condition.