The phrase "be very picture of" means to embody or exemplify a certain quality or characteristic. Its antonyms, then, would be words or phrases that indicate the opposite or a lack of that quality. These could include terms such as "uncharacteristic of," "unrepresentative of," or "opposite of." Using these antonyms would suggest that the subject being described does not meet the expected standard or is lacking in the desired qualities. For example, if someone is said to be the "very picture of health," using an antonym could indicate that they are unwell, unhealthy, or out of shape.