Comediennes, referring to female comedians, has various antonyms depending on the context. If we talk about serious individuals, some antonyms may include "grave," "earnest," or "solemn." If we consider someone who will not play for laughs or show contentment, antonyms may include "sad," "serious," or "stoic." In addition, if someone lacks humor and laughter, some antonyms may include "humorless," "dour," or "unamusing." Lastly, if we consider someone that creates sadness or depression instead of joy or laughter, some antonyms may include "depressing," "tragic," or "unfunny." It greatly depends on the context in which the antonyms are being applied to the original word.