Antonyms for "controlled clinical trials randomized" could include "uncontrolled observational studies non-randomized," "non-evidence-based interventions," or "unscientific trial designs." These antonyms represent studies that do not employ rigorous methodologies, and may not have valid, generalizable results. Uncontrolled, non-randomized studies may lack control groups, randomization, or blinding, which may introduce biases and confounding variables. Non-evidence-based interventions may lack scientific support, and may not have been thoroughly tested in controlled trials. Unscientific trial designs may use untested or unproven methods, or may employ methodologies that do not meet current scientific standards. Overall, these antonyms represent studies that may not provide reliable, accurate, or generalizable results, and should be interpreted with caution.