Crow-Fukase syndrome, also known as POEMS syndrome, is a rare disease that affects multiple systems in the body. The acronym "POEMS" stands for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. This syndrome is often accompanied by symptoms such as numbness, weakness, fatigue, difficulty breathing, and skin discoloration. Other synonyms for Crow-Fukase syndrome include Takatsuki syndrome, osteosclerotic myeloma-like disease, and plasma cell dyscrasia. While the exact cause of this syndrome is unknown, it is believed to be related to abnormal protein production in the body. Although there is no cure for this condition, treatments such as chemotherapy, radiation therapy, and stem cell transplantation may be used to manage symptoms.