Denatures refers to the process of altering a protein's shape, resulting in the loss of its biological activity. There are several synonyms that can be used in place of denatures, including coagulates, deteriorates, degrades, and decomposes. These terms all imply that a substance has undergone a change in its chemical or physical composition, resulting in a loss of its original properties. Other synonyms for denatures include corrupts, spoils, and taints, all of which convey a negative connotation and suggest that the original substance has been polluted or contaminated. Regardless of the specific word used, denatures always refers to a significant alteration or deformation of a protein's structure or function.