"Dewy-eyed" commonly refers to a person who is naive, innocent, and inexperienced. Therefore, antonyms for "dewy-eyed" may include words like cynical, jaded, experienced, and seasoned. A person who is cynical is likely to be distrustful and skeptical, while someone who is jaded may be weary, bored, or disillusioned. Similarly, a person who is experienced or seasoned has likely dealt with the challenges of the world and gained knowledge and insight from their experiences. Other potential antonyms for "dewy-eyed" may include words like shrewd, astute, or worldly, all of which suggest a level of knowledge and awareness that is the opposite of naivety.