DNA topoisomerases are critical enzymes for controlling the topological state of DNA. They function by catalyzing the breaking and rejoining of the DNA strands, allowing DNA to be efficiently compacted and replicated. There are several synonyms for DNA topoisomerases, such as DNA gyrase, DNA decatenase, and DNA untwisting enzyme. DNA gyrase is responsible for supercoiling DNA, whereas DNA decatenase is important for separating intertwined DNA molecules. The DNA untwisting enzyme is responsible for relieving torsional strain in DNA. Understanding the various functions and synonyms for DNA topoisomerases is essential in elucidating their roles in DNA replication, transcription, and repair.