"Dost a takeoff" is an archaic phrase that was commonly used in Shakespearean times to mean "prepare to leave" or "get ready to depart." There are several modern synonyms that can be used in place of this phrase. Some alternatives include "prepare to depart," "get ready to take off," "be on your way," "make your move," or "hit the road." Depending on the context and tone, other options might include "time to go," "let's get out of here," or simply "goodbye." With so many options available, anyone looking for a more contemporary way to convey the meaning of "dost a takeoff" should have no trouble finding a suitable synonym.