"Dramatic locomotor defects" refers to significant impairments in a person's ability to move, walk or run, and can be due to various medical conditions or injuries. Synonyms for this term include "grave motor dysfunction," "severe ambulatory impairment," "profound gait abnormalities," and "pronounced motor dysfunction." Other possible synonyms for dramatic locomotor defects could include "crippling mobility issues," "debilitating locomotion dysfunction," "serious motoric anomalies," or "serious ambulation deficiencies." Regardless of the phrasing, these synonyms all convey the seriousness of the condition and the significant impact it can have on a person's quality of life.