"Druther" is a colloquial term that is commonly used in the United States to express a preference or choice. While it is a unique word, there are several synonyms that can be used interchangeably. For example, "preference" is a synonym for "druther" as they both express a personal choice. "Choice" is another suitable synonym for "druther," particularly in situations where a decision needs to be made. Other synonyms for "druther" include "option," "desire," "liking," and "wish." Therefore, if someone is looking to express their inclination or choice, they can use any of these synonyms in place of "druther" to convey their preference effectively.