Dr. Boileau, quoted above, himself contracted leprosy of which he died; he experimented on himself with "hydrocotyle" and on one occasion a dose of 3 grams nearly proved fatal; tetanic symptoms supervened with suffocation, palpitation, epistaxis and rectal hemorrhage, abating finally with profuse sweating and diuresis.
"The Medicinal Plants of the Philippines"
T. H. Pardo de Tavera
When the medial wall is fractured and the nasal fossa opened into, epistaxis and emphysema of the orbit are constant symptoms.
"Manual of Surgery Volume Second: Extremities--Head--Neck. Sixth Edition."
Alexander Miles Alexis Thomson