"First off" is a commonly used phrase that introduces the initial point of discussion or explanation. However, there are other phrases that can be used in its place to add variety and avoid repetition. For example, "to begin with" can emphasize the start of the conversation while "initially", "firstly" and "in the first place" can convey the same meaning in a more formal tone. "First and foremost" is also a popular alternative that conveys importance. Additionally, "for starters", "in the beginning" and "at the outset" are more conversational options that can be used interchangeably with "first off." By using different synonyms for "first off," one can avoid sounding repetitive and keep the conversation interesting and engaging.