Frommels Disease, also known as cerebrooculofacioskeletal (COFS) syndrome, is a rare genetic disorder that affects the brain and nervous system. This syndrome is characterized by a combination of brain abnormalities, visual impairment, skeletal malformations, and growth delays. Although often referred to as Frommels Disease, it is crucial to note its synonym, COFS syndrome, to ensure accurate communication within the medical community. Individuals diagnosed with this condition may experience severe developmental delays, seizures, feeding difficulties, and a limited life expectancy. Synonyms like COFS syndrome help healthcare professionals and researchers identify and categorize this rare disorder accurately, enabling them to collaborate and advance knowledge about the disease's clinical presentation, potential treatments, and supportive care.