Gargoylism is a rare genetic disorder that affects physical development and causes intellectual disability. There are several synonyms for this condition, including Hurler syndrome, MPS I, or mucopolysaccharidosis type I. These terms are often used interchangeably to describe the same condition. Other similar disorders with overlapping symptoms include Hunter syndrome, Sanfilippo syndrome, and Morquio syndrome. All of these conditions are caused by a deficiency in enzymes that help break down complex carbohydrates. Despite the complexity of these disorders, researchers are making steady progress in understanding their underlying mechanisms and developing new treatments to manage the symptoms and improve outcomes for affected individuals.