Globoid cell leukodystrophy is a rare inherited disorder that causes the destruction of the protective myelin sheath around nerve fibers. Some synonyms for globoid cell leukodystrophy include Krabbe disease, galactosylceramide lipidosis, and globoid cell leukoencephalopathy. Krabbe disease is named after the physician who first described the disorder in 1916. Galactosylceramide lipidosis refers to the buildup of a specific type of fat molecule within cells, which causes the damage seen in globoid cell leukodystrophy. Globoid cell leukoencephalopathy refers to the degeneration of the white matter in the brain, which is a hallmark of the disease. Currently, there is no cure for globoid cell leukodystrophy, but early detection and treatment can help manage symptoms and improve quality of life.