"Go cuckoo" is an informal expression used to describe someone who has lost their sanity or is acting in a crazy manner. There are several synonyms that can be used instead of "go cuckoo" to convey the same idea. One such phrase is "lose one's mind," which means to become mentally unstable. Another similar expression is "go insane," which implies a complete loss of rational thought. "Flip out" is another informal term that can be used to describe someone behaving erratically. Other synonyms include "go nuts," "go bonkers," and "go off the deep end." Regardless of the phrase used, all convey the same message of someone behaving in a crazy manner.