The phrase "going in smoke" often refers to something disappearing or being wasted with no positive outcome. The antonym for this phrase would be something like "a fruitful endeavor" or "a productive outcome." Instead of resources or efforts wasted, there would be an accomplishment, a success, or a gain. For example, if a project or plan went "in smoke," the antonym would be if it was completed on time, within budget, and met all the expectations. Likewise, if a person's career or future seemed to be "going in smoke," the antonym would be if they found their dream job or achieved success in their chosen field. Ultimately, the antonym of "going in smoke" is a positive and desirable outcome.