The phrase "come to nothing" is often used to express disappointment or frustration when someone's efforts or plans fail to produce the desired result. There are many synonyms that can be used instead of this phrase, such as "fizzle out," "collapse," "fall through," "come to naught," "be in vain," "come to a dead end," "end in failure," "come to a halt," "break down," "go down the drain," and "amount to little." These synonyms can add variety and depth to one's vocabulary, and allow for more nuanced expression of disappointment.