There are a variety of synonyms that can be used for the phrase "do in". Some possible options include the terms "exhaust", "fatigue", "wear out", "tire", "drain", "sap", "weaken", "enervate", "enfeeble", "debilitate", and "overwhelm". These words all convey a sense of physical or mental exertion or strain that can leave someone feeling depleted, worn down or incapacitated. Whether used in reference to a particular task, activity or overall state of being, these terms can add nuance to our language, helping us to convey a more precise and evocative sense of our experiences and emotions.