"Take it out of you" is a common phrase used to describe a situation where someone is exhausted or drained mentally and physically. The phrase can be replaced with synonyms like exhaust, deplete, wear out, sap, drain, tire out, fatigue, enervate, and tax. The synonyms have different shades of meaning and can be used in different contexts to convey the degree of tiredness or exertion. For instance, sap and deplete suggest a gradual loss of strength, while exhaust implies a complete and sudden loss of energy. Using synonyms can add variety and nuance to your writing, making it more interesting and engaging for your readers.