Getting exhausted is something that can happen to anyone, and when it does, it's always helpful to have a variety of synonyms to express that feeling. Here are some alternatives for "tire out". "Drain" is a great option that conveys the sense of being physically and/or mentally depleted. "Weary" is another highly descriptive word that captures that sense of being worn down. Other options include "exhaust", "enervate", "fatigue", "devitalize", "prostrate", and "sap". Each of these words is perfect for expressing the feeling of being completely wiped out, and they are all great options to have in any writer's vocabulary.