Louse up is a common phrase that indicates a situation where something has gone wrong or been spoiled in some way. There are various synonyms for this word, words that can help to diversify your language and make your communication more precise. A few examples of synonyms for louse up include derail, screw up, botch, mess up, ruin, spoil, flub, and bungle. Although they all express the same meaning, each word has a slightly different connotation and usage. For instance, if you are writing a formal report, you may prefer to use 'derail' instead of 'louse up,' while 'screw up' may be used in causal conversations or casual writing. Using synonyms for louse up can help you to express yourself more accurately.