The phrase "makes muck of" can have a negative connotation, implying that something or someone is making a mess or causing chaos. There are several synonyms that can be used to convey a similar meaning, such as "disrupts," "ruins," "corrupts," "confuses," "undermines," "derails," "stifles," "sabotages," "hinders," "spoils," and "destroys." Each of these words suggests that the action being taken is having a negative impact on the situation, and can be used interchangeably with "makes muck of" to convey this sentiment.