Antonyms for the phrase "makes most of" include terms like squander, waste, underutilize, neglect, and overlook. When someone squanders an opportunity, they fail to take advantage of a chance to succeed or make progress. Those who waste what they have been given are effectively throwing away resources or failing to use them effectively. Underutilization refers to not using resources to their full potential, whereas neglect suggests a failure to care for what has been entrusted to someone. Finally, an overlook implies neglecting or failing to notice something important, which could ultimately have significant consequences.