Confuse, bewilder, baffle, mystify, puzzle, perplex, flummox, thwart, dismay, disorient, complicate, confute, puzzle, stump, nonplus, obfuscate, befuddle, frustrate, astonish, dumbfound, stagger, startle, astound, amaze, dumbstruck, stupefy, bewilder, throw, surprise, mix up. These are some of the synonyms for the word "confound". They are all powerful words that could be used to describe the state of mind that one could be in when they are unable to understand or comprehend something. Using any of these words in place of "confound" could bring depth and value to any sentence.