The word "in-spirits" signifies the act of uplifting, motivating, or cheering someone up. The antonyms of "in-spirits" would be words that represent the opposite of these positive emotions. Some of the antonyms for "in-spirits" are demoralize, dishearten, discourage, depress, and deflate. These are terms that describe a sense of sadness, hopelessness, and negativity, representing a lack of enthusiasm and inspiration. When someone is demoralized or disheartened, they may feel unmotivated and uninspired, and their energy to pursue their goals and dreams may be diminished. Therefore, it is essential to surround ourselves with people and things that "in-spirit" us, so we can stay positive, focused, and motivated to achieve our desired outcomes.