The phrase "rough-and-tumble" refers to a physical struggle or a rowdy, uncontrolled situation. Some synonyms for this phrase include "brawl," "scuffle," "melee," "fracas," and "fisticuffs." Another term that can be used in a similar context is "tussle," which implies a more playful or less serious encounter. "Altercation," "confrontation," and "quarrel" are also related terms that could be used interchangeably with "rough-and-tumble" in certain situations. These words all convey the sense of a chaotic, energetic conflict, where there is little regard for rules or order.