The antonyms for the phrase "make uneasy" can be varied depending on the context. If we take the psychological aspect of making someone uneasy, the antonyms can be comforting, soothing, tranquilizing, or lulling. These words have the opposite effect on the human psyche and can promote relaxation, security, and calmness. If we take a more physical approach where making someone uneasy can be equated to hindering or stopping them, then the antonyms can be facilitating, promoting, aiding, encouraging, or inspiring. These words imply helping or motivating someone to move forward and enhance their skills, knowledge or capabilities. Whatever the context, the antonyms for "make uneasy" always promote positivity and support.