Hemoglobin H disease is a genetic blood disorder that affects the production of hemoglobin protein in red blood cells. It is caused by mutations in the alpha-globin genes and can result in anemia, splenomegaly, and jaundice. Hemoglobin H disorder is also known as Alpha-thalassemia, Alpha-thalassemia major, hemoglobin Bart's disease, or thalassemia H. These terms are used interchangeably to describe this rare condition. Other synonyms for hemoglobin H disease include HbH, Alpha-thalassemia intermedia, or HbH-Constant Spring disease. While there is no cure for hemoglobin H disease, symptoms can be managed through blood transfusions, iron chelation therapy, or bone marrow transplantation.