The antonyms for "holds high esteem" are "disparages," "disrespects," "underestimates," and "undervalues." When someone disparages or disrespects another person, they do not see them as being worthy of admiration or respect. Underestimating or undervaluing someone implies that they do not have many significant qualities or achievements, and, thus, their contribution is not as valuable. The opposite of holding someone in high esteem can be harmful and damaging, as it may lead to neglecting, underestimating, or undervaluing someone. Therefore, it's essential to foster respect and appreciation for other people and their accomplishments.