Holoprosencephaly is a rare brain malformation that occurs during fetal development. Due to its unique name, it may be challenging to find synonyms for this condition. However, some alternative terms for holoprosencephaly include holoprosencephalia, alobar holoprosencephaly, semilobar holoprosencephaly, and lobar holoprosencephaly. These terms refer to specific variations of holoprosencephaly that differ in the degree of brain malformation. While these synonyms may not be commonly used in everyday conversation, they are important to know for healthcare professionals, researchers, and families affected by this condition. Early detection and intervention are essential for improving outcomes and quality of life for those with holoprosencephaly.